Denmark

Danish National Biobank

The Danish National Biobank is one of the world’s largest biobanks. With more than 10 million samples from around 3 million individuals, the DNB is a rich resource of population-based cohorts and biological samples, linked with detailed information from the Danish Biobank Register. The database includes genome-wide association study (GWAS) data from 150,000 individuals, as well as whole exome sequencing (WES) results from 35,000 individuals.

Key facts

Name of the connected EIT Health partner:Lasse Boding
Number of individuals:~ 3,000,000
– BSBM: 87,275
– Diagnostic samples: 843,558
– Greenland samples: 16,896
– PKU: 2,005,020
Biobank confirmed willingness to provide samples/data for EIT Health studies:Yes
Contact person(s) and contact data
(e-mail address, tel. no) for access purposes:
Lasse Boding, labo@ssi.dk,
+4532689163
Number of samples:Total 10,100,000
– Unique on register: 4,300,000
– BSMB: 442,478
– Diagnostic samples: 1,591,306
– Greenland samples: 37,600
– PKU: 2,035,954
Sample types:Samples in the collection represent a wide range of disease categories, and are derived from diverse sources including serum, dried blood spot, plasma, whole blood, DNA, buffy coat, urine, saliva, red blood cells, amniotic fluid, cord blood mononuclear cells, DBSS protein extracts, and spinal fluid.
Omics data:GWAS data are available from 150,000 individuals. WES from 35,000
Website:Danish National Biobank

General information

Type of biobank:Population-based cohorts, diagnostic samples, clinical samples.
If longitudinal the frequency:Many donors have multiple sample types and samples from several time points in the biobank.
Link to central portal to seek samples and data:Danish Biobank Register www.biobanks.dk
Broad consent:Varies. Population-based studies broad consent. Diagnostic samples opt-out register.
Option to recall donors:Yes (most), No (diagnostic samples).
Option to recall family members:Yes (most), No (diagnostic samples).

Quality management system:

Link to operational procedures:Not available
Storage:Samples are handled and stored according to standard procedures.
Compliance with international standards:Biobank ISO accreditation (20378) primo 2020.
Current ISO certificates:In progress.

Data:

Clinical data linked to samples:Samples can be linked to clinical data in registries and laboratory test databases.
Data standards:Data are handled according to internal procedures.
Data security rules:Data security is provided by the Danish Health Data Authority. (https://sundhedsdatastyrelsen.dk/da) 

Biobank related service:

Research support, what type of expertise?:Data managers, statisticians, laboratory personnel.
Core facility services; what type? Link?:Sample storage, preparation, distribution. DNA-extraction, normalization. Biomarker analysis.
Queries from national health registers:Yes, via Danish Biobank Register (www.biobanks.dk)
Links to the model contract and MTA:Not yet available online

IP:

IP rules, what is negotiable?:Very little.
Requirements to study results (access etc.):Researchers must be willing to deliver back analysis results, so other researchers can obtain access to it. The legal and IT solutions required to effectuate this is still being created.
Participant’s right to the information:Do quite a lot of public engagement. Participate in science festivals in Denmark and the large political festival “Folkemodet” every June on Bornholm.
Number of access contracts with industry:Very many. Regarding sample storage, biomarker analysis and retrieval of biological samples.
Statistics about access if available:Not available.

The "Registers and Biobanks in Transition” strategic initiative is funded by EIT Health